Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography.

reportActive / Technical Report | Accession Number: ADA136981 | Open PDF

Abstract:

A simple differential-pulse polarographic D.p.p. method has been developed for the analysis of minoxidil in pharmaceutical dosage forms. The extracting solvent was methanol and the supporting electrolyte was 1.0 N sulphuric acid. An excellent linear relationship was obtained between concentration and current peak height with a correlation coefficient of 0.9999. Good agreement was obtained between results with the d.p.p. method and those by the manufacturers method of assay. There was no interference by the tablet excipients. In acid solution, a mechanism for reduction at -1.2 V is proposed which involves four electrons transferred as well as dehydration and deamination steps. Author

Author(s):
Amankwa, L. ; Chatten, L. G. ; Pons, S.
Author Organization(s):
UTAH UNIV SALT LAKE CITY DEPT OF CHEMISTRY
Descriptive Note:
Technical rept.,
Pagination:
0022

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
TR-22
Contract/Grant Number(s):
N00014-83-K-0470
 Subject Terms
Joint Capability Areas:
JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_5_Command and Control; JCA_5.3_Planning; JCA_6.3.3_Spectrum Management; JCA_1_Force Support; JCA_6_Net Centric; JCA_1.2_Force Preparation; JCA_1.4_Force Support; JCA_6.3_Net Management
Modernization Areas:
Directed Energy
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*Electrochemistry, *Drugs, *Polarography, Coulometers, Voltammetry, Tablets(Chemical), Dosage, Chemical analysis, Extraction, Solvents, Carbinols, Electrolytes, Sulfuric acid, Electric current, Height, Coefficients, Diffusion, Vasodilation
Field(s)/Group(s):
Pharmacology, Physical Chemistry
Keyword(s):
Minoxidil, Antihypertensive drugs, Differential pulse polarography, Vasodialators, WUNR359718
Report Date:
1984 Jan 16