Studies on the Enzymatic Hydrolysis of Organophosphate Poisons in Pigs.

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Abstract:

Phosphate paraoxon was studied in Yorkshire pig, rat and human sera. Enzymatic hydrolysis was significantly affected by certain buffers in the reaction mixture. Kinetic measurements suggest that more than one enzyme hydrolyzes the organophosphate. Depending on pH and substrate concentration, inhibition of the enzymes by paraoxon is or is not observed. Enzymatic activity in human serum increases with a rise in pH whereas in pig serum activity decreases. Author

Author(s):
Schmid, Peter ; Jaeger, June
Author Organization(s):
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Descriptive Note:
Final rept. May 81-Jul 82,
Pagination:
0031

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
LAIR-133
Project Number(s):
3M161102BS10
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_6.3.3_Spectrum Management; JCA_5.2_Understand; JCA_6_Net Centric; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_6.3_Net Management; JCA_3.2_Engagement; JCA_3_Force Application; JCA_5.3_Planning; JCA_3.2.1_Kinetic Means; JCA_5.3.3_Develop Strategy; JCA_1_Force Support
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*POISONS, *ORGANOPHOSPHATES, IONS, RATS, HUMANS, ENZYMES, BLOOD SERUM, HYDROLYSIS, PH FACTOR
Field(s)/Group(s):
Toxicology
Keyword(s):
PE61102A, ASS10
Report Date:
1982 Nov 01