Investigation of Intermediary Metabolism and Energy Exchange Following Human Trauma.

Kinney, John M.

Investigation of Intermediary Metabolism and Energy Exchange Following Human Trauma.

Active / Technical Report | Accession Number: ADA103120 |

Open PDF

Abstract:

Insulin to glucagon IG ratios were found to be higher in portal than in peripheral blood in human subjects in the postabsorptive state and after injections of glucose or alanine. This reflects greater removal of insulin than of glucagon by the liver. Nevertheless, peripheral IG ratio provides an index of the portal ratio since there is good correlation between the two. Studies are in progress of the effects of total parenteral nutrition on transport of glucose, amino acids, fatty acids and other substrates between liver and leg in depleted or septic human subjects. Coterminous measurements are also made of nitrogen and energy balance and hormone concentrations. We plan to initiate studies of oxidation and clearance in human subjects of intravenous fat emulsions labelled with 14C. Author

Author(s):

Kinney, John M.

Author Organization(s):

COLUMBIA UNIV NEW YORK COLL OF PHYSICIANS AND SURGEONS

Descriptive Note:

Annual rept. 1 Jan-31 Dec 75,

Supplementary Note:

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

RECORD

Collection: TR

Identifying Numbers

Contract/Grant Number(s):

DA-49-193-MD-2552

Subject Terms

Joint Capability Areas:

JCA_6.2.3_Core Enterprise Services; JCA_6_Net Centric; JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_6.2_Enterprise Services; JCA_1.2_Force Preparation; JCA_1_Force Support; JCA_1.2.3_Educating; JCA_5_Command and Control; JCA_5.3_Planning

Communities of Interest:

No COI(s) Identified

Descriptor(s):

*METABOLISM, *TRAUMA, *INSULIN, *BLOOD CHEMISTRY, *GLUCAGON, HUMANS, LIVER, NUTRITION, AMINO ACIDS, GLUCOSE, BIOLOGICAL ABSORPTION, LEGS, CATABOLISM, PARENTERAL INFUSIONS, BLOOD ANALYSIS, FATTY ACIDS, TRACER STUDIES, GLYCERIDES

Field(s)/Group(s):

Biochemistry, Anatomy and Physiology, Medicine and Medical Research

Report Date:

1976 Oct 07