The Role of Endorphins in the Pathophysiology of Shock and the Therapeutic Benefit of Opiate Antagonists,

Holaday, John W.; Faden, Alan I.

The Role of Endorphins in the Pathophysiology of Shock and the Therapeutic Benefit of Opiate Antagonists,

Active / Technical Report | Accession Number: ADA090403 |

Abstract:

Evidence is presented that the pure opiate antagonist naloxone rapidly increases blood pressure and decreases mortality associated with shock caused by endotoxemia, hemorrhage, and spinal-cord transection. Shock studies conducted in rats, cats, and dogs demonstrate these therapeutic effects of naloxone across a variety of species. Additionally, naloxone treatment significantly improves neurologic recovery paralysis after spinal-cord injury in the cat. Results from additional experiments provide evidence for the site and mechanisms of these therapeutic effects of naloxone.

Author(s):

Holaday, John W. ; Faden, Alan I.

Author Organization(s):

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Pagination:

0014

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

RECORD

Collection: TR

Subject Terms

Joint Capability Areas:

JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_3_Force Application; JCA_3.2_Engagement; JCA_1.2.5_Lessons Learned; JCA_3.2.1_Kinetic Means

Modernization Areas:

Microelectronics

Communities of Interest:

Counter IED

Descriptor(s):

*DRUGS, *PHARMACOLOGICAL ANTAGONISTS, *NARCOTICS, STABILIZATION, RATS, THERAPY, DOGS, SHOCK(PATHOLOGY), BLOOD PRESSURE, OPIUM ALKALOIDS, CATS

Field(s)/Group(s):

Pharmacology

Keyword(s):

*Endorphins, *Naloxone

Report Date:

1980 Jun 01