Classes and Properties of Human Antibodies.

Some preliminary experiments on establishing a mouse model for human atop were done. The hypothesis to be tested is that atopy is based upon an increased permeability of relatively low molecular weight proteins and perhaps other macromolecules through respiratory and perhaps other mucous membranes. Ovomucoid and BPO-ovomucoid were selected as antigens. Some initial experiments to immunize mice via nebulized antigen were done. No clear cut serum antibodies were found in mice so treated. However, there was anaphylactic response to injected antigen in some mice. This is a preliminary result which needs confirmation before it can be accepted as real. Author