Mutagen and Oncogen Study on JP-8

reportActive / Technical Report | Accession Number: ADA064948 | Open PDF

Abstract:

The material evaluated in this study was subjected to a matrix of in vitro assays employing microbial cells, mammalian cells in culture and in vivo tests measuring potential germ cell effects in mice and rats. The test compound, JP-8 Tanic F-3, produced a moderate increase in unscheduled DNA synthesis in WI- 38 cells. These data suggest that the material could interact with DNA producting nonspecific lesions. No evidence for mutagenicity was evident in the test battery and the indications for mutagenic and carcinogenic potential for this compound are minimal at best. There is no suggestion of significant genetic risk associated with this material.

Author(s):
Brusick, David ; Matheson, Dale W.
Author Organization(s):
LITTON BIONETICS INC KENSINGTON MD
Descriptive Note:
Final rept.
Pagination:
0059

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AMRL-TR-78-20
Contract/Grant Number(s):
F33615-77-C-0518
Task Number(s):
01
Project Number(s):
6302
Monitor Series:
TR-78-20, AMRL
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_5.3.3_Develop Strategy; JCA_5.3.4_Develop Courses of Action; JCA_5.3.5_Analyze Courses of Action; JCA_1.2.7_Experimentation; JCA_5.6.1_Assess Compliance with Guidance; JCA_5.6_Monitor; JCA_1.2.5_Lessons Learned
Modernization Areas:
Fully Networked C3
Communities of Interest:
Biomedical
Descriptor(s):
*TOXIC HAZARDS, *DEOXYRIBONUCLEIC ACIDS, *MUTAGENS, *ONCOGENESIS, *JET ENGINE FUELS, ACTIVATION, MICE, CULTURES(BIOLOGY), LYMPHOMAS, SALMONELLA TYPHIMURIUM, MICROBIOLOGICAL TESTS, MICROSOMES, GENETICS, CELLS(BIOLOGY), CARCINOGENS, RATS, TOXICITY
Field(s)/Group(s):
Medicine and Medical Research, Toxicology
Keyword(s):
*CARCINOGENESIS, JP 8 TANIC F 3, ONCOGENS, JP 8 FUEL, PE62202F, WUAMRL63020154
Report Date:
1978 Sep 01