Investigation of N,N-Diethyl-M-Toluamide(M-Det) for Dominant Lethal Effects in the Mouse.

Swentzel, Kipling C.

Investigation of N,N-Diethyl-M-Toluamide(M-Det) for Dominant Lethal Effects in the Mouse.

Active / Technical Report | Accession Number: ADA058414 |

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Abstract:

A single dose of N,N-diethyl-m-toluamide m-Det in corn oil was administered to male mice by gavage in a dominant lethal assay to evaluate its potential mutagenicity in male germ cells. The compound did not induce a positive mutagenic response during an 8-week mating period in which each of 10 males was cohoused weekly with 3 untreated virgin females, although there was a slight, but statistically insignificant reduction in the total number of fetal implants. This reduction was probably not genetic in origin. Triethylenemelamine TEM, which served as the positive control, induced a dominant lethal response during weeks 1, 2, 3 and 6 of mating. Author

Author(s):

Swentzel, Kipling C.

Author Organization(s):

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Descriptive Note:

Final rept. Sep-Nov 77,

Pagination:

0012

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

RECORD

Collection: TR

Identifying Numbers

Report Number(s):

USAEHA-51-0034-78

Subject Terms

Joint Capability Areas:

JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_5_Command and Control; JCA_5.3_Planning

Communities of Interest:

Biomedical

Descriptor(s):

*INSECT REPELLENTS, *GERM CELLS, MUTATIONS, PHYSIOLOGICAL EFFECTS, MALES, MICE

Field(s)/Group(s):

Toxicology

Keyword(s):

Toluamide N, N Diethyl M

Report Date:

1977 Nov 01