Characterization of Exotoxin of 'Pseudomonas aeruginosa'

reportActive / Technical Report | Accession Number: ADA049790 | Open PDF

Abstract:

Heat-labile exotoxin of Pseudomonas aeruginosa has been purified and concentrated. Studies in mice have shown that the toxin affects protein synthesis in the liver within 3 hr of administration, whereas inhibition of protein synthesis in other organs occurs only during terminal stages. In short- term experiments in vitro, purified exotoxin did not inhibit ingestion or killing of bacteria by human polymorphonuclear leukocytes.

Author(s):
Pavlovskis, Olgerts R. ; Callahan, Iii., Lynn T. ; Meyer, Richard D.
Author Organization(s):
NAVAL MEDICAL RESEARCH INST BETHESDA MD
Descriptive Note:
Medical research progress rept.
Supplementary Note:
Pub. in The Jnl. of Infectious Diseases, v130, Suppl Nov 1974.
Annotation:
Reprint: Characterization of Exotoxin of 'Pseudomonas aeruginosa'
Pagination:
0005

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Task Number(s):
MF51524016
Project Number(s):
F51524
Monitor Series:
NMRI
 Subject Terms
Joint Capability Areas:
JCA_1.2.7_Experimentation; JCA_1_Force Support; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_8_Building Partnerships
Communities of Interest:
Biomedical
Descriptor(s):
*EXOTOXINS, REPRINTS, MICE, LIVER, PSEUDOMONAS AERUGINOSA, PROTEIN METABOLISM, INGESTION(PHYSIOLOGY), INHIBITION, BIOSYNTHESIS, POLYMORPHONUCLEAR LEUKOCYTES
Field(s)/Group(s):
Biochemistry, Toxicology
Keyword(s):
PHAGOCYTOSIS, PE62758N, WU0002
Report Date:
1974 Jan 01