'Plasmodium berghei berghei': Irradiated Sporozoites of the ANKA Strain as Immunizing Antigens in Mice

reportActive / Technical Report | Accession Number: ADA049670 | Open PDF

Abstract:

Mice were protected against challenge with infective sporozoites following immunization with X-ray irradiated sporozoites. The immunity lasted at least 8 weeks. Mice immune against sporozoite challenge remained fully susceptible to challenge with erythrocytic stages. Immunization of mice with extracts of mosquito thorax failed to protect them, indicating that mosquito antigens were not directly responsible for the immunity observed in the basic experiments.

Author(s):
Beaudoin, Richard L. ; Strome, Cloyce P. ; Tubergen, Theodore A. ; Mitchell, Fred
Author Organization(s):
NAVAL MEDICAL RESEARCH INST BETHESDA MD
Descriptive Note:
Medical research progress rept.
Supplementary Note:
Pub. in Experimental Parasitology, 39 p438-443, 1976.
Pagination:
0007

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Task Number(s):
MR0410901, MF51524009
Project Number(s):
MR04109, F51524
Monitor Series:
BUMED
 Subject Terms
Joint Capability Areas:
JCA_1.2.7_Experimentation; JCA_1_Force Support; JCA_1.4_Force Support; JCA_6_Net Centric
Communities of Interest:
Biomedical
Descriptor(s):
*PLASMODIUM BERGHEI, *SPOROZOITES, *VACCINES, ANOPHELES, ANTIGENS, ERYTHROCYTES, IMMUNIZATION, IMMUNOGENS, INFECTIOUS DISEASE TRANSMISSION, IRRADIATION, MALARIA, MICE, REPRINTS, STRAINS(BIOLOGY), X RAYS
Field(s)/Group(s):
Medicine and Medical Research, Radiobiology, Microbiology
Keyword(s):
ANOPHELES STEPHENSI, PE61153N, PE62758N, WU0127B6GJ, WU0032BB61
Report Date:
1975 Jul 21