Immunological Studies on Herion Addiction.

reportActive / Technical Report | Accession Number: ADA048215 | Open PDF

Abstract:

Hemagglutination-inhibition HI procedures for the detection of morphine, methadone and barbiturates have been devised, developed and validated to the point of their adoption by diagnostic laboratories, and the necessary reagents have become available through commercial sources. The HI test for the detection of the major cocaine metabolites suffers from interference by unidentified substances found in some human urine specimens. After appropriate adjustment for this interference the test detects cocaine metabolites for about 4 days after last use of the drug. HI tests for detection of amphetamine and LSD have yet to be completely developed. The application of serological methods for the study of pharmacokinetics has been critically examined and the results have been submitted for publication. Finally, the generation of specific antibodies in response to morphine administration has been verified, but the biological significance of this phenomenon remains in question. Author

Author(s):
Liu, Chi-tan ; Adler, Frank L.
Author Organization(s):
PUBLIC HEALTH RESEARCH INST OF THE CITY OF NEW YORK INC
Descriptive Note:
Final rept. Jul-Sep 75,
Pagination:
0010

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
2052-5
Contract/Grant Number(s):
DADA17-72-C-2052
 Subject Terms
Communities of Interest:
Biomedical
Descriptor(s):
*DETECTION, *SENSITIVITY, *IMMUNIZATION, *DRUG ADDICTION, CHEMICAL REACTIONS, ANTIBODIES, IMMUNOLOGY, IMMUNOASSAY, SEROLOGY, COCAINE, METABOLITES, SERODIAGNOSIS, DRUG ABUSE, HEROIN
Field(s)/Group(s):
Medicine and Medical Research
Report Date:
1975 Oct 01