The Effects of Acute Alterations in Hemodynamics, Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa.

Using a previously described model for acute gastric mucosal ulcerogenesis Gastroent. 68699, 1975, studies indicated that methylprednisolone significantly protects against acute lesion formation by enhancing mucosal blood flow that, at constant concentration of bile acid, lesion formation is a linear function of the concentration of hydrogen ion and that, under non-ischemic conditions, in addition to affection significant inhibition of histamine stimulated H secretion, metiamide produces a concomitant reduction in venous alkaline-tide. Finally, it was also shown that concomitant histamine infusion neither protects nor augments lesion formation under the experimental circumstances described.