The Protective Effect of Melanin against Radiation.

reportActive / Technical Report | Accession Number: ADA033604 | Open PDF

Abstract:

Oxidation and reduction of autoxidative dopa-melanin were studied. Reduction with neither ascorbic acid nor sodium dithionite led to any overall increase in the number of 5,6-dihydroxyindole units in the melanin polymer. The melanin was oxidised using repsectivley potassium ferricyanide and ceric sulphate solutions but in neither case was the melanin e.s.r. signal diminished. The interaction of melanins free radicals with cupric ions was shown not to be chemical in nature. The number of bound cupric ions was determined and the value used to calculate the number of free radicals in autoxidative dopa-melanin.

Author(s):
Swan, George A. ; Baldry, Patricia A.
Author Organization(s):
NEWCASTLE-UPON-TYNE UNIV (ENGLAND) DEPT OF ORGANIC CHEMISTRY
Descriptive Note:
Final technical rept. Oct 75-Oct 76,
Pagination:
0021

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DA-ERO-75-G-054
Task Number(s):
00
Project Number(s):
1T161102B71D
 Subject Terms
Joint Capability Areas:
JCA_6.3.3_Spectrum Management; JCA_6.3_Net Management; JCA_6_Net Centric; JCA_1.2.7_Experimentation; JCA_1_Force Support; JCA_1.2.5_Lessons Learned; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.1_Kinetic Means; JCA_1.2_Force Preparation
Communities of Interest:
Energy and Power Technologies
Descriptor(s):
*RADIOPROTECTIVE AGENTS, *MELANIN, ELECTRONS, OXIDATION, COPPER, FREE RADICALS, PHENYLALANINE
Field(s)/Group(s):
Radiobiology
Keyword(s):
Radiation effects(Biology), PE61102A, AS71D, WU456
Report Date:
1976 Oct 01