Ethanol-Induced Depletion of Cerebellar Guanosine 3',5'-Cyclic Monophosphate Levels.

Redos, J. D.; Catravas, G. N.; Hunt, W. A.

Ethanol-Induced Depletion of Cerebellar Guanosine 3',5'-Cyclic Monophosphate Levels.

Active / Technical Report | Accession Number: ADA033403 |

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Abstract:

Single doses of ethanol induce a severe depletion 95 percent of cerebellar guanosine 3-5-cyclic monophosphate C-GMP levels within 1 hour after administration. The degree of this depletion is a function of the amount of ethanol in the blood. Interactions between ethanol and C-GMP may account for some of the intoxicating properties of ethanol. The results of this study provide further information on the development and exploration of models for chronic insults to the brain, such as long-term exposure to toxic chemicals and ionizing and nonionizing radiation. Author

Author(s):

Redos, J. D. ; Catravas, G. N. ; Hunt, W. A.

Author Organization(s):

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Descriptive Note:

Scientific rept.,

Pagination:

0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

RECORD

Collection: TR

Identifying Numbers

Report Number(s):

AFRRI-SR76-24

Subject Terms

Joint Capability Areas:

JCA_3.2_Engagement; JCA_3_Force Application

Communities of Interest:

Biomedical

Descriptor(s):

*BRAIN, *PHOSPHATES, *ETHANOLS, DEPLETION, RATS, CLINICAL MEDICINE, DOSAGE, LEVEL(QUANTITY), THERAPY, EXPOSURE(PHYSIOLOGY), IN VIVO ANALYSIS, IONIZING RADIATION, BLOOD CIRCULATION, INTOXICATION

Field(s)/Group(s):

Biochemistry, Medicine and Medical Research

Keyword(s):

Guanosine 3 5 cyclic monophosphate, Monophosphate Guanosine 3 5 cyclic, C GMP(Guanosine 3 5 cyclic Monophosphate), Adenosine 3 5 cyclic monophosphate, Monophosphate Adenosine 3 5 cyclic, C AMP(Adenosine 3 5 cyclic Monophosphate)

Report Date:

1976 Jun 01