Developments in Quantitative Structure-Activity Relationships (QSAR). A Review

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Abstract:

Three different approaches have been developed by groups headed by Hansch, Holmes and by Free and Wilson to the problem of quantitative structure- activity relationships QSAR of drugs to biological processes and these have been reviewed and the strengths and weaknesses of each method annotated.

Author(s):
Holmes, H. L.
Author Organization(s):
DEFENCE RESEARCH ESTABLISHMENT SUFFIELDRALSTON (ALBERTA)
Pagination:
0138

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
DRES-282
Project Number(s):
20-03-05
Monitor Series:
DRES
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_1.3.2_Personnel Management; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_1.2.7_Experimentation
Communities of Interest:
Biomedical
Descriptor(s):
*PHARMACOLOGY, METHODOLOGY, QUANTITATIVE ANALYSIS, REACTION KINETICS, CHEMICAL PROPERTIES, PARAMETERS, THERMODYNAMICS, EXTRAPOLATION, ENZYMES, CANADA, AROMATIC COMPOUNDS, PHARMACOKINETICS, DRUGS, CORRELATION TECHNIQUES
Field(s)/Group(s):
Pharmacology
Keyword(s):
*STRUCTURE ACTIVITY, HANSCH EQUATIONS
Report Date:
1976 Jul 01