Toxicology of Cyclotrimethylenetrinitramine (RDX): Distribution and Metabolism in the Rat and the Miniature Swine.

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Abstract:

Cyclotrimethylenetrinitramine RDX is an explosive extensively used by the military. It has caused convulsions in military field personnel ingesting it and in munition workers inhaling its dust during manufacture. At least one fatality was attributed to RDX toxicity in an European munitions manufacturing plant. In this country, RDX has been dumped into open pits for disposal after demilitarization, and in some instances has contaminated surface and ground water. It is possible that humans might be exposed to RDX in potable water. This study, initiated at the request of the Naval Medical Research and Development Command, was intended to determine the distribution, metabolism and excretion of RDX in laboratory animals and to estimate by inference the potential hazard to humans from RDX exposure.

Author(s):
Schneider, N. R. ; Bradley, S. L. ; Andersen, M. E.
Author Organization(s):
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Descriptive Note:
Scientific rept.,
Pagination:
0028

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AFRRI-SR76-34
Task Number(s):
C903, MF57572001
Project Number(s):
DNA-NWED-QAXM, MF57.572
 Subject Terms
Joint Capability Areas:
JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.1_Kinetic Means
Communities of Interest:
Biomedical
Descriptor(s):
*EXPLOSIVES, *RDX, *TOXICOLOGY, MILITARY PERSONNEL, HAZARDS, RATS, HUMANS, TOXICITY, METABOLISM, DRINKING WATER, WATER POLLUTION, DOSAGE, MUNITIONS INDUSTRY, PUBLIC HEALTH, DOSE RATE, BIOASSAY, LABORATORY ANIMALS, SWINE, EXCRETION
Field(s)/Group(s):
Toxicology, Ammunition and Explosives
Keyword(s):
Potable water, Environmental health
Report Date:
1976 Jul 01