A Quantitative Assay to Measure Physostigmine in Human Whole Blood.

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Abstract:

This report describes a quantitative assay method for measuring physostigmine in human whole blood. Blood samples are maintained at 37 C, and cholinesterase activity is measured periodically. The time required for enzyme reactivation is related to physostigmine concentration. The precision of the method is within or - 4 over a physostigmine concentration range of 0.5 to 5.0 x 10 to the minus 7th power molliter. Author

Author(s):
Groff, William A. ; Ellin, Robert I. ; Skalsky, Rickie L.
Author Organization(s):
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
Descriptive Note:
Technical rept. Jan 73-Jan 75,
Pagination:
0017

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
EB-TR-76020
Task Number(s):
1W762718AD1904
Project Number(s):
DA-1-W-762718-AD-19
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CHOLINESTERASE INHIBITORS, LABORATORY TESTS, QUANTITATIVE ANALYSIS, REACTION KINETICS, HUMANS, ENZYMES, TIME, CHOLINESTERASE, CONCENTRATION(CHEMISTRY), TOXICOLOGY, CARBAMATES, BLOOD ANALYSIS, BLOOD CHEMISTRY
Field(s)/Group(s):
Toxicology, Pharmacology
Keyword(s):
*Physostigmine, Autoanalyzers
Report Date:
1976 Feb 01