Hazard Evaluation of Candidate Face Net Impregnant, ENT-80, 4-Biphenylol.

A hazard evaluation of the candidate face net impregnant, technical grade 4-biphenylol ENT-80, was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. No corneal injury, iritis or conjunctivitis was observed after a single application of the technical grade compound to the eyes of rabbits. No skin sensitization reaction in guinea pigs or photochemical irritation in rabbits was seen with this compound. Data indicate little acute toxic hazard from accidental ingestion. Acute aerosol, as well as acute and subchronic vapor, inhalation exposures of rats resulted experimentally in no deleterious effect. It is recommended that ENT-80 be approved for testing as a candidate face net impregnant.