Blocking Action of Snake Venom Neurotoxins at Receptor Sites to Putative Central Nervous System Transmitters.

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Abstract:

A general survey of crude venom from snakes of four different families revealed that several venoms which are known to operate at peripheral cholinergic junctions in vertebrates also interfere with cholinergic receptor sites in molluscan central nervous system tissue, and that venom from one snake, Vipera russelli, may contain a fraction which selectively interferes with dopamine receptor sites. Several additional experiments concerning the structure and mechanisms of both cholinergic and dopaminergic transmission are proposed and certain snake venoms are suggested for further investigation as possibly valuable pharmacological probes in future experiments of receptor pharmacology. Author

Author(s):
Parmentier, J. ; Carpenter, D. O.
Author Organization(s):
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Descriptive Note:
Scientific rept.,
Pagination:
0024

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AFRRI-SR75-19
Task Number(s):
C912
Project Number(s):
DNA-NWED-QAXM
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*SNAKES, *VENOMS, *PARASYMPATHOLYTIC AGENTS, PROBES, PRECURSORS, VERTEBRATES, NERVOUS SYSTEM, CENTRAL NERVOUS SYSTEM, TOXINS AND ANTITOXINS, CHOLINERGIC NERVES, NERVE TRANSMISSION, MOLLUSCA, EPINEPHRINE
Field(s)/Group(s):
Toxicology
Keyword(s):
Vipera russelli venom, Bungarus multicinctus venom, Crotalus durissus terrificus venom, Echis carinatus venom, Dopamine receptor sites, Snake venoms
Report Date:
1975 Jun 01