Use of Tetanus Allergen for Determining the Sensitivity of People to Tetanus Anatoxin

The authors discuss the problem of a possibility of using tetanus allergen for detection of increased sensitivity of man to tetanus toxoid. Two allergens--the first from the toxoid, and the second from the microbial cells, were investigated. In parallel with intradermal tests, a determination was made of the titre of the antitoxin circulating in the blood. It was shown that the action of the allergens was specific--a local reaction in the form of hyperemia always appeared in persons whose blood antitoxin level was greater than 0.001 IUml.