Nature and Control of Side-Reactions Due to Diethylcarbamazine in the Treatment of Malayan Filariasis.

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Abstract:

The chemotherapy against human filariasis has developed since Santiago-Stevenson 1947 had reported that 1-diethylcarbamyl-4-methyl-piperazine hydrochloride has an activity of the rapid disappearance of microfilaria from the peripheral blood. And many trials of mass treatment by this compound have ever been made by the investigators all over the world. However, because of the adverse reactions after drug administration, it is urgently necessitated to know the nature and control of these reactions, particularly in the treatment of malayan filariasis, in order to bring the successful results in the chemotherapeutic control measure of this nematodiasis. Studies on several dose schedules and the histopathology of adverse reactions are discussed.

Author(s):
Seo, Byong-seol
Author Organization(s):
SEOUL NATIONAL UNIV (REPUBLIC OF KOREA) DEPT OF PARASITOLOGY
Descriptive Note:
Final rept. 27 Jul 73-26 Jul 74,
Supplementary Note:
See also Annual report no. 2, AD-768 738.
Pagination:
0068

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DA-RDRF-S92-544-74-G207
Task Number(s):
2N061102B71D00
Project Number(s):
DA-2-N061102-B-71-D
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CHEMOTHERAPEUTIC AGENTS, *FILARIASIS, *ANTHELMINTICS, DOSAGE, PATHOLOGY, RESPONSE(BIOLOGY), DRUGS, SOUTH KOREA, PARASITIC DISEASES, TOXICOLOGY, HELMINTHIC DISEASES
Field(s)/Group(s):
Pharmacology
Keyword(s):
*Diethylcarbamazine
Report Date:
1974 Oct 21