Human Cell Line Activation Test of the Novel Energetic N,N'- bis(4 nitro 1,2,5 oxadiazol 3 yl)-methanediamine (MBANF)

reportActive / Technical Report | Accession Number: AD1099566 | Open PDF

Abstract:

The energetic and toxicological properties of n,n-bis4-nitro-1,2,5-oxadiazol-3-yl-methanediamine MBANF are under assessment as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RD and trinitrotoluene TNT. This study evaluated the skin sensitization hazard of MBANF through the h-CLAT, an in vitro approach to assess activation of dendritic cells. Data from the h-CLAT were also utilized to predict a Hazard Category UNECE2015 for acute oral toxicity. Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for development of new munition compounds.

Author(s):
Reinke, Emily N.
Author Organization(s):
Army Public Health Center Aberdeen Proving Ground United States
Descriptive Note:
Technical Report,01 Feb 2020,31 Mar 2020
Pagination:
0040

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release;

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
S.0070548-19
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1.2.7_Experimentation; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.1_Kinetic Means; JCA_1.4_Force Support; JCA_6_Net Centric; JCA_1.4.1_Force Health Protection; JCA_6.1_Information Transport; JCA_5.4_Decide; JCA_1_Force Support; JCA_1.4.2_Health Service Delivery; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_8_Building Partnerships; JCA_1.2_Force Preparation; JCA_5.4.3_Establish Rule Sets; JCA_6.4.1_Secure Information Exchange; JCA_1.2.1_Training
Communities of Interest:
No COI(s) Identified
Descriptor(s):
cell lines, toxicity, toxicology, rdx, tnt, SKIN (ANATOMY), sensitivity, data analysis, reactivities, range finding, public health, ENVIRONMENTAL HEALTH
Field(s)/Group(s):
Anatomy and Physiology, Environmental Health and Safety
Keyword(s):
skin sensitization, h clat(human cell line activation test)
Report Date:
2020 Mar 01
Creation Date:
2020 May 27