The Imprint of Psychogenic Non-Epileptic Seizures on the Brain: A New Model and Imaging Biomarker

reportActive / Technical Report | Accession Number: AD1063800 | Open PDF

Abstract:

The goal of the project is to obtain evidence that supports a new mechanism that assumes that PNES are caused by a predisposition for enhanced synchronizationovershooting recruitment of brain regions involved in emotion controlprocessing of traumaticstressful experiences. By assuming such a predisposition, the project implicitly assumes that PNES have a specific biological underpinning. The first year of the project was spent on finalizing questionnaires and report forms , obtaining IRB approval from all participating institutions, development and implementation of MR imaging protocol and image processing pipelines, hiring and training research personnel. The project got permission to enroll participants in 0518. Since then 28 potential PNES patients have been screened and 1 PNES has been enrolled and has completed the assessments.

Author(s):
Mueller, Susanne G.
Author Organization(s):
Northern California Institute of Research and Education San Francisco United States
Descriptive Note:
Technical Report,30 Sep 2017,29 Sep 2018
Pagination:
0016

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release;

RECORD

Collection: TR
Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_1_Force Support; JCA_6_Net Centric; JCA_5.5.2_Task; JCA_5.5_Direct; JCA_6.1_Information Transport; JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_1.3_Human Capital Management; JCA_1.3.2_Personnel Management; JCA_5.3_Planning; JCA_8_Building Partnerships; JCA_1.2_Force Preparation; JCA_8.2_Shape; JCA_1.2.1_Training; JCA_1.2.5_Lessons Learned; JCA_8.1_Communicate; JCA_8.2.1_Partner with Governments and Institutions; JCA_8.2.2_Provide Aid to Foreign Partners and Institutions; JCA_1.2.3_Educating; JCA_5.4_Decide
Modernization Areas:
Autonomy
Communities of Interest:
Biomedical
Descriptor(s):
SEIZURES, brain, Stress (Psychology), TRAUMA, HUMAN EMOTIONS, Magnetic resonance imaging, TRAUMATIC STRESS DISORDER
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
FMRI(Functional magnetic resonance imaging), PNES(Psychogenic non epileptic seizures), overshooting, PTSD(Post Traumatic Stress Disorder)
Report Date:
2018 Oct 01
Creation Date:
2018 Nov 27