Liquid Chromatography Tandem Mass Spectrometry in Toxicology and Environmental Sciences Research and Education Programs

reportActive / Technical Report | Accession Number: AD1063245 | Open PDF

Abstract:

The purpose of this proposal was to seek a matching fund to acquire a liquid chromatography tandem mass spectrometry LC-MSMS instrument for John Jay College, a senior college within the City University of New York and a Minority-Serving Institution, to enhance its research capabilities and improve its educational program. Thanks to this award, the equipment ultra-fast liquid chromatograph Nexera, UFLC-XR coupled to a triple quadrupole mass spectrometer LCMS-8050 from Shimadzu Corporation was installed in the Toxicology Laboratory in John Jay College in September 2016. The installation was completed on September 8th 2016, and the PI Marta Concheiro-Guisan and the co-PIs Shu-Yuan Cheng and Yi He attended the corresponding training on September 12th, 19th and 21st 2016. Since then, the equipment has been employed in undergraduate and graduate projects in Human Performance and Biosystems and Environmental Chemistry research areas. A total of 3 undergraduate students and 4 graduate students have been utilizing this instrument in their corresponding research projects. The main problem studied with the equipment since its installation has been the waste-water analysis of tobacco and illicit drugs in New York City. Wastewater-based toxicology is an innovative and promising approach that provides information about exposure to external agents, such as drugs of abuse and medicines, in defined population groups by the analysis of human excretion products biomarkers in wastewater. Traces of almost everything we consume are excreted unchanged or as a mixture of metabolites in our urine andor feces and ultimately end up in the sewer network 1. This approach is best described as large urine test, as the collective wastewater represents anonymous urine samples of thousands of individuals. By measuring the levels of licit and illicit drugs and their metabolites in wastewater, the quantity of drugs consumed in a community can be estimated 2.

Author(s):
Concheiro-guisan, Marta ; Cheng, Shu Y ; He, Yi
Author Organization(s):
Research Foundation of CUNY New York United States
Descriptive Note:
Technical Report,01 Aug 2016,31 Jul 2017
Pagination:
0012

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release;

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
ARO-68834-CH-REP.3
Monitor Series:
ARO-68834-CH-REP.3
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2_Force Preparation; JCA_1_Force Support; JCA_1.2.3_Educating; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_5.3.3_Develop Strategy; JCA_5.3.4_Develop Courses of Action; JCA_5.3.5_Analyze Courses of Action; JCA_6_Net Centric; JCA_8_Building Partnerships; JCA_6.2.3_Core Enterprise Services; JCA_8.2_Shape; JCA_6.1_Information Transport; JCA_1.2.1_Training; JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_6.2_Enterprise Services; JCA_8.2.1_Partner with Governments and Institutions
Communities of Interest:
No COI(s) Identified
Descriptor(s):
liquid chromatography, mass spectrometry, toxicology, ecology, Waste water, drugs
Field(s)/Group(s):
Test Facilities, Equipment and Methods, Miscellaneous Detection and Detectors, Toxicology, Ecology
Keyword(s):
lc msms (liquid chromatography tandem mass spectrometry)
Report Date:
2017 Oct 31
Creation Date:
2018 Nov 08