Development of Technology for Image-Guided Proton Therapy

This report describes continued work on the award Neurocognitive Effects of Radiotherapy, which examines the neurocognitive and imaging impact of proton therapy for patients will low grade glioma and base of skull meningioma. A total of 58 patients have been enrolled. All cohort 1 and 2 patients have completed a 4-5 hour neurocognitive testing assessment at baseline by Dr. Carol Armstrong. In addition, cohort patients have completed a 1 hour standard MRI as well as additional testing including diffuse tensor imaging DTI, perfusion and diffusion. Thirty-four patients have completed neurocognitive and imaging evaluation at planned time points. Dr. Michelle Alonso-Basanta is Principle Investigator for this. Catherine Feinstein is the Clinical Research Coordinator managing the associated IRB-approved protocol. Dr. Christine Hill-Kayser is the Project Manager for this section of the award. Further budgetary details are outlined in the attached document.