Follistatin: A Potential Anabolic Treatment for Re-Innervated Muscle

reportActive / Technical Report | Accession Number: AD1044365 | Open PDF

Abstract:

Follistatin is a possible anabolic treatment for denervation atrophy induced muscle weakness following prolonged denervation. Adenovirus delivery of Recombinant FS-288 DNA isoform does not induce hypertrophy in normal rodent gastrocnemius muscle. The efficacy of Adenoassociated virus delivery of FS-288 DNA or direct delivery of recombinant FS-288 protein is currently not known.

Author(s):
Isaacs, Jonathan
Author Organization(s):
Virginia Commonwealth University Richmond United States
Descriptive Note:
Technical Report,15 Aug 2016,14 Aug 2017
Pagination:
0025

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release;

RECORD

Collection: TR
Identifying Numbers
Project Number(s):
0010703362-0002
 Subject Terms
Joint Capability Areas:
JCA_1.4.1_Force Health Protection; JCA_1.4_Force Support; JCA_6_Net Centric; JCA_3.2_Engagement; JCA_3_Force Application; JCA_6.4.1_Secure Information Exchange; JCA_3.2.2_Non-Kinetic Means; JCA_6.4_Information Assurance; JCA_5_Command and Control; JCA_5.3_Planning; JCA_4.3_Maintain; JCA_1_Force Support; JCA_1.2_Force Preparation; JCA_1.2.5_Lessons Learned; JCA_8_Building Partnerships; JCA_1.2.3_Educating; JCA_8.2_Shape
Communities of Interest:
No COI(s) Identified
Descriptor(s):
ATROPHY, nerves, muscles, wounds and injuries, proteins, deoxyribonucleic acids, drugs
Field(s)/Group(s):
Biochemistry, Anatomy and Physiology, Pharmacology
Keyword(s):
FOLLISTATIN, ANABOLIC treatments, DENERVATION ATROPHY, NERVE Injuries, NERVE REPAIR, Re Innervated Muscle, Adenovirus delivery, Recombinant FS 288 DNA isoforms, dna (deoxyribonucleic acids)
Report Date:
2017 Sep 01
Creation Date:
2018 Jan 09