Non invasive Imaging based Detection and Mapping of Brain Oxidative Stress and its Correlation with Cognative Functions

Brain stress level measurement non-invasively in quantitative term is very helpful to correlate with various neuropsychological outcome. Brain protective anti-oxidant called glutathione level is affected with aging process due to increased stress. This pilot project is the first human study to measure the brain glutathione level and also perform various neuropsychological test to investigate any possible correlation between glutathione GSH level and neuropsychological outcome. We have found that at the age of 40 onwards, there is a depletion of brain glutathione level and these subject population above 40Y face more difficult to perform certain neuropsychological tests, which is easily performed by young subject below 35Y old.