Human Cell Line Activation Test of the Novel Energetics 2,6-pyrazinediamine 3,5-dinitro 1 -oxide (LLM-105) and 2,4,6-trinitro-3-bromoanisole (TNBA)

Human Cell Line Activation Test of the Novel Energetics 2,6-pyrazinediamine 3,5-dinitro 1 -oxide (LLM-105) and 2,4,6-trinitro-3-bromoanisole (TNBA)

Active / Technical Report | Accession Number: AD1042154 |

Abstract:

The energetic and toxicological properties of 2,6-pyrazinediamine 3,5-dinitro-1 -oxide LLM-105 and 2,4,6-trinitro-3-bromoanisole TNBA are being determined to support an evaluation of LLM-105 and TNBA as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RDX and trinitrotoluene TNT. This study assessed the skin sensitization potential of LLM-105 and TNBA through the human cell line activation test h-CLAT, an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the induction of a skin allergy. Both compounds induced a positive response in the assay.

Author(s):

Reinke, Emily N.

Author Organization(s):

Army Public Health Center Aberdeen Proving Ground United States

Descriptive Note:

Technical Report,01 Jan 2017,01 Nov 2017

Pagination:

0035

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:

Approved For Public Release

Distribution Statement:

Approved For Public Release;

RECORD

Collection: TR

Identifying Numbers

Report Number(s):

S.0039820-16

Subject Terms

Joint Capability Areas:

JCA_5_Command and Control; JCA_5.3_Planning; JCA_1.2.5_Lessons Learned; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.1_Kinetic Means; JCA_1.4_Force Support; JCA_6_Net Centric; JCA_1.2.7_Experimentation; JCA_8_Building Partnerships; JCA_1.4.1_Force Health Protection; JCA_1_Force Support; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_6.1_Information Transport; JCA_1.1_Force Management; JCA_6.4.1_Secure Information Exchange

Communities of Interest:

No COI(s) Identified

Descriptor(s):

cell line, SKIN (ANATOMY), toxicology, ENERGETIC MATERIALS, OCCUPATIONAL SAFETY AND HEALTH, SENSITIVITY, antibodies, assays, fluorescence

Keyword(s):

TNBA (2 4 6 trinitro 3 bromoanisole), LLM 105 (2 6 pyrazinediamine 3 5 dinitro 1 oxide), skin sensitization, h clat (human cell line activation test), in vitro, flow cytometry, rfi (relative fluorescence intensity), mfi (mean fluorescence intensity)

Report Date:

2017 Nov 06

Creation Date:

2017 Dec 08