Chikungunya Arthritis Mechanisms in the Americas (CAMA): A cross sectional analysis of chikungunya arthritis patients 22 months post-infection demonstrates a lack of viral persistence in synovial fluid

reportActive / Technical Report | Accession Number: AD1037359 | Open PDF

Abstract:

Chikungunya virus CHIKV is a mosquito-borne virus that causes chronic joint pain for months 46 to years in approximately one half of infected patients. The study objective was to determine if CHIKV persists in the synovial fluid, potentially serving as a causative mechanism of persistent arthritis.

Author(s):
Chang, Aileen Y ; Martins, Karen A ; Encinales, Liliana ; Acuna, Marlon ; Encinales, Carlos ; Matranga, Christian ; Pacheco, Nelly ; Cure, Carlos ; Shukla, Bhavarth ; Arteta, Teofilo R ; Amdur, Richard ; Cazares, Lisa H ; Gregory, Melissa ; Ward, Michael D ; Porras, Alexandra ; Mendoza, Alejandro R ; Dong, Lian ; Kenny, Tara ; Brueggemann, Ernie ; Downey, Lydia G ; Kamalapathy, Priyanka ; Lichtenberger, Paola ; Falls, Orlando ; Simon, Gary L ; Bethony, Jeffrey ; Firestein, Gary S ; Reid, St. Patrick
Author Organization(s):
USAMRIID Ft Detrick United States
Descriptive Note:
Journal Article - Open Access
Supplementary Note:
PLoS Neglected Tropical Diseases Journal , 01 Jan 0001, 01 Jan 0001,
Pagination:
0021

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release;

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
TR-17-119
 Subject Terms
Joint Capability Areas:
JCA_5.3_Planning; JCA_5_Command and Control; JCA_1.2.3_Educating; JCA_1.2.5_Lessons Learned
Modernization Areas:
Fully Networked C3
Communities of Interest:
No COI(s) Identified
Descriptor(s):
infectious diseases, arthritis, chemical reactions, MOSQUITO BORNE DISEASES, joint diseases, proteins, antibodies
Field(s)/Group(s):
Medicine and Medical Research
Report Date:
2017 Jun 30
Creation Date:
2017 Jun 30