Regulation of Pituitary Beta Endorphin Release: Role of Serotonin Neurons

reportActive / Technical Report | Accession Number: AD1010648 | Open PDF

Abstract:

Beta-Endorphin-like immunoreactivity B-END-LI is present In highest concentration in the anterior AL and intermediate lobe IL of the pituitary gland from where it is released in response to pain and other stimuli. Several lines of evidence suggest that serotonin neurons influence nociception via mechanisms which involve opiate receptors and the release of endogenous opiate peptides within the central nervous system CNS and possibly from the pituitary. The purpose of the presentresearch was to determine whether serotonin neurons are involved in the regulation of pituitary B-END-LI secretion and therefore provide evidence for a functional relationship between serotonergic-stimulated release of pituitary B-END-LI and endogenous mechanisms of analgesia. Since the pituitary is the major source for blood-borne B-END-LI, the effects of serotonergic drugs on plasma levels of B-END-LI was used to study serotonergic control over pituitary 3-endorphin.

Author(s):
Malcolm, Diana S.
Author Organization(s):
Uniformed Services University Of The Health Sciences Bethesda United States
Descriptive Note:
Technical Report
Pagination:
0198

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release;

RECORD

Collection: TR
Subject Terms
Joint Capability Areas:
JCA_1.2.5_Lessons Learned; JCA_5_Command and Control; JCA_1.2.7_Experimentation; JCA_5.3_Planning; JCA_1.2.3_Educating; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_JCA_4.1.2_Sustain the Force; JCA_4.1_Deployment and Distribution
Modernization Areas:
Autonomy
Communities of Interest:
No COI(s) Identified
Descriptor(s):
Pituitary gland, serotonin, peptides, central nervous system, Secretion, analgesia, drugs, blood plasma, Endorphins, Tryptophan, brain, drugs, Biosynthesis, neurons, receptor sites (physiology), sampling, tissues (biology), assaying, Stimulation (Physiology)
Keyword(s):
b end li (Beta Endorphin like immunoreactivity), b lph (Beta lipotropin), serotonin neurons, crf (Corticotropin Releasing Factor), Electrical Stimulation
Report Date:
1983 Dec 15
Creation Date:
2017 Feb 28