(1) Pathogenesis, Detection, Prevention and Treatment of Infectious Diseases of Military Importance. (2) Human Leukoxyte Migration Inhibition: An Assay for Endotoxemia. (3) Mechanisms of Endotoxin Tolerance. IX. Effect of Early Exchange Transfusion on Endotoxin Lethality

reportActive / Technical Report | Accession Number: AD0777539 | Open PDF

Abstract:

The Division of Infectious Diseases of the University of Maryland School of Medicine continues to maintain a volunteer research ward at the Maryland House of Correction, Jessup, Maryland. The purpose of this facility has been to serve as a base for investigations in volunteers of various uniquely human infectious diseases. These studies have been aimed primarily at the evaluation of various vaccines. In recent years the effort has been directed at enteric infections of military importance. Quantitative measurements of effectiveness of oral typhoid and shigella vaccines have been carried out. In addition, attempts have been made to uncover the significance of pathogenesis of and host resistance to infection with the presumed viral agent of winter vomiting disease, enterotoxigenic E. coli and penetrating E. coli. Availability of these human models has allowed for cooperative research projects to explore the role of endotoxin in infectious diseases, and to attempt to define mechanisms of immunity, i.e., cellular versus humoral. The status of these studies is presented in the report.

Author(s):
Hornick, Richard B. ; Blotzer, Wolfe ; Woodward, Celeste L. ; Greisman, Sheldon E. ; Dubuy, Bernard
Author Organization(s):
MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE
Descriptive Note:
Annual rept. for 1973
Pagination:
0050

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release, Document Partially Illegible
Distribution Statement:
Availability: Document Partially Illegible.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DA-49-193-MD-2867
Task Number(s):
3A762760A83401
Project Number(s):
DA-3-A-762760-A-834
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_1.4_Force Support; JCA_1.4.1_Force Health Protection; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_1_Force Support; JCA_8_Building Partnerships; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_1.2_Force Preparation; JCA_1.3_Human Capital Management; JCA_1.2.5_Lessons Learned; JCA_1.2.3_Educating; JCA_3_Force Application; JCA_6_Net Centric; JCA_1.3.2_Personnel Management; JCA_3.2_Engagement; JCA_5_Command and Control; JCA_1.2.7_Experimentation; JCA_1.4.2_Health Service Delivery; JCA_6.4.1_Secure Information Exchange
Modernization Areas:
Fully Networked C3
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*MILITARY MEDICINE, *INFECTIOUS DISEASES, ESCHERICHIA COLI, DIAGNOSIS(MEDICINE), VIRUS DISEASES, IMMUNITY, PATHOGENIC MICROORGANISMS, BACTERIAL DISEASES, GASTROINTESTINAL DISEASES, VACCINES, SHIGELLA, ENDOTOXINS, CHEMOTHERAPY, SALMONELLA TYPHOSA
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
TYPHOID, EVALUATION
Report Date:
1974 Feb 25