Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.

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Abstract:

A sensitive in vitro method has been set up which measures the stimulation of the hexose monophosphate shunt HMS in normal and glucose-6-phosphate dehydrogenase G6PD deficient red blood cells. It has been used to measure and compare the stimulation produced by methylene blue, primaquine, sulphalene, fanasil, DFD and the experimental drug WZB 08271. These drugs stimulate the HMS in normal red cells but are unable to do so in G6PD deficient cells. In view of these results it is presumed that drugs capable of stimulating the HMS in normal red cells would cause lysis of G6PD deficient red cells in vivo. This prediction has been confirmed in studies using chromium labelled G6PD-deficient red cells in vivo. Author

Author(s):
Salvidio, E. ; Gaetani, G. ; Ajmar, F. ; Ravazzolo, R. ; Ghio, R.
Author Organization(s):
ISTITUTO DI EMATOLOGIA GENOA (ITALY)
Descriptive Note:
Final technical rept. Dec 72-Nov 73,
Pagination:
0015

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
ERO-E-1551
Contract/Grant Number(s):
DAJA37-73-C-1494
Monitor Series:
E-1551
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*Antimalarials, *Drugs, Erythrocytes, Deficiencies, Enzymes, Hexoses, Hemolysis, Biochemistry, Italy
Field(s)/Group(s):
Pharmacology
Keyword(s):
*Dehydrogenase glucose 6 phosphate, Hexose phosphates
Report Date:
1973 Dec 01