A Safe and Convenient Preparation of Isopropyl Methylphosphonylated Acetylcholinesterase.

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Abstract:

Isopropyl methylphosphonylated acetylcholinesterase is conveniently and safely prepared by the reaction of acetylcholinesterase with isopropyl m-nitrophenyl methylphosphonate in the presence of fluoride ion. This alternative to the conventional pathway using neat and highly toxic isopropyl methylphosphonofluoridate Sarin offers the combined advantages of the esters lower toxicity, ready preparation and purification, and convenience of storage and use. Modified author abstract

Author(s):
Balthis, Vernon M. ; Lennox, Willard J. ; Hovanec, Joseph W. ; Lieske, Claire N. ; Steinberg, George M.
Author Organization(s):
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
Descriptive Note:
Technical rept. Nov 71-Jan 72,
Pagination:
0020

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
EA-TR-4754, EB-TR-73010
Task Number(s):
1W662710AD2502
Project Number(s):
DA-1-W-662710-AD-25
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*ACETYLCHOLINESTERASE, GB AGENT, CHEMICAL DERIVATIVES, SYNTHESIS(CHEMISTRY)
Field(s)/Group(s):
Biochemistry
Keyword(s):
*Phosphonates, Nitro compounds
Report Date:
1973 Dec 01