Rejection Mechanisms in Corneal Transplantation.

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Abstract:

The report details efforts to characterize the transplantation antigens of the cornea as encountered in xenogeneic keratoplasty. Three protein factions have been isolated from the cornea. Each has been shown to possess transplantation antigen activity as demonstrated by its ability to induce a specific sensitization resulting in the accelerated destruction of a subsequent corneal graft. The antigenic fractions are also capable of stimulating the production of humoral antibodies. The relationship between the transplantation immunity and the antibody response will be discussed. Author

Author(s):
Leibowitz, Howard M. ; Freidman, Ephraim
Author Organization(s):
BOSTON UNIV MASS SCHOOL OF MEDICINE
Descriptive Note:
Final scientific rept.,
Supplementary Note:
See also AD-705 675.
Pagination:
0007

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DADA-17-69-C-9109
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CORNEA, *TRANSPLANTATION, *IMMUNOLOGY, *ANTIGEN ANTIBODY REACTIONS, TRANSPLANTATION, TRANSPLANTATION, ANTIGENS, ANTIBODIES, IMMUNITY
Field(s)/Group(s):
Medicine and Medical Research
Keyword(s):
*XENOGENIC KERATOPLASTY, KERATOPLASTY
Report Date:
1973 Oct 15