The Effect of Supralethal Doses of Ionizing Radiation Upon Mitochondria of the Rat Central Nervous System,

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Abstract:

The effect of supralethal doses of ionizing radiation upon the function of rat central nervous system CNS mitochondria was studied. Following 20,000 rads to the head there was a significant transient decrease in respiratory control, with a return to control levels by 4 hours after irradiation. Despite this apparent return to normal respiratory function the animals continued to deteriorate clinically, dying of the radiation CNS syndrome within 48 hours. In animals receiving 10,000 rads to the head, there were no apparent abnormalities in the respiratory function of the mitochondria. The results suggest that mitochondira of the CNS are quite radio-resistant when compared to those of other tissues, and this may in part explain the greater radioresistance of the CNS when compared to other organs. Author

Author(s):
Cohan, S. L. ; Catravas, G. N. ; Abbott, J. R. ; Ricks, E. E.
Author Organization(s):
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Pagination:
0016

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AFRRI-SR72-12
Task Number(s):
C902
Project Number(s):
DNA-NWER-XAXM
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
(*RADIATION EFFECTS, MITOCHONDRIA), (*MITOCHONDRIA, CENTRAL NERVOUS SYSTEM), (*CENTRAL NERVOUS SYSTEM, RADIATION EFFECTS), PERMISSIBLE DOSAGE, RADIATION DOSAGE, RESPIRATORY SYSTEM, RADIATION TOLERANCE, PARTIAL BODY IRRADIATION, RATS, EXPERIMENTAL DATA
Field(s)/Group(s):
Radiobiology
Keyword(s):
*IONIZING RADIATION
Report Date:
1972 Jul 01