Effects of Heat and Exercise on the Elimination of Pralidoxime Chloride in Man.

Pralidoxime chloride, used clinically to reactive cholinesterase in organophosphate poisoning, is rapidly eliminated by the kidney. In these studies, heat and exercise stress significantly decreased the renal excretion of both pralidoxime and p-aminohippurate PAH, used to estimate renal plasma flow in man. Pharmacokinetic data suggest that overall drug removal from plasma is also affected by changes in tissue distribution of these drugs with stress conditions there is a marked increase in volumes of drug distribution. Furthermore, decreased total recovery of drugs in the urine under heat and exercise conditions implicates tissue metabolism as a factor of heretofore undetermined significance in the overall elimination of both pralidoxime and PAH. Author