Preparation and Research on Meningococcal Vaccines

reportActive / Technical Report | Accession Number: AD0740762 | Open PDF

Abstract:

A contract was arranged between the U.S. Department of Defense and Merck Co., Inc. to prepare on a feasability basis 20 gms. of meningococcal polysaccharide vaccine, type C and on a best-effort basis up to 20 gms. of meningococcal polysaccharide vaccine, type A. The methodology for general vaccine preparation and control testing was established by the U.S. Army and was supplied to Merck Co., Inc. in the form of specifications. The duration of the contract was from October 6, 1970 to December 31, 1971. The contractual committment was met on schedule. Slightly more than 20 gms. of meningococcal polysaccharide vaccine, type C was produced 413,350 x 50 mcg doses. The material was produced as eight separate lots, each of which met the specifications of the contract. They were delivered as lyophilized formulations. Release protocols describing the preparation and control testing procedures and results for each of the lots accompanied the vaccines. A summary of the lot numbers and quantities delivered is included.

Author(s):
Hilleman, Maurice R.
Author Organization(s):
MERCK AND CO INC RAHWAY NJ
Descriptive Note:
Rept. no. 4 (Final), 1 Nov 1971-1 Mar 1972
Supplementary Note:
See also report dated 31 Oct 1971, AD734079.
Pagination:
0078

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DADA17-71-C-1029
Monitor Series:
USAMRDC
 Subject Terms
Joint Capability Areas:
JCA_5_Command and Control; JCA_5.3_Planning; JCA_6_Net Centric; JCA_8_Building Partnerships; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_6.4.1_Secure Information Exchange; JCA_6.1_Information Transport; JCA_6.4_Information Assurance; JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.2_Non-Kinetic Means; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_8.2.4_Leverage Capacities and Capabilities of Security Establishments; JCA_8.2_Shape
Modernization Areas:
Directed Energy
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*VACCINES, *NEISSERIA MENINGITIDIS, STABILITY, PREPARATION, BACTERIA, POLYSACCHARIDES, QUALITY CONTROL, STANDARDS, STORAGE, IMMUNOLOGY, PRESERVATION
Field(s)/Group(s):
Microbiology
Report Date:
1972 Mar 01