Some Effects of CBrF3 Inhalation and Epinephrine Challenge on Certain Myocardial Metabolite Levels.

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Abstract:

Bromotrifluoromethane CBrF3 would have considerable potential as a closed environment fire extinguishing agent, except for its membership in that large group of hydrocarbons capable of precipitating irregular heart action when inhaled by persons with elevated levels of blood epinephrine. These experiments were an effort to determine whether myocardial metabolism was impaired in male Wistar rats breathing 7921 CBrF3O2 and challenged with 1-epinephrine in what would ordinarily constitute sub-toxic dosages. CNS effects were the major observations in rats exposed to both CBrF3 and epinephrine all control rats survived without apparent effect. The general picture was consistent with the CBrF3 induction of respiratory depression and hypoxia. Author

Author(s):
Rhoden, Richard A.
Author Organization(s):
NAVAL AIR DEVELOPMENT CENTER WARMINSTER PA CREW SYSTEMS DEPT
Descriptive Note:
Interim rept.,
Pagination:
0061

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
NADC-CS-7114
Project Number(s):
NADC-IR-R000-01-01/21
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
(*HALOGENATED HYDROCARBONS, TOXICITY), (*CARDIOVASCULAR SYSTEM, HALOGENATED HYDROCARBONS), ARRHYTHMIA, RESPIRATION, EPINEPHRINE, CENTRAL NERVOUS SYSTEM, HYPOXIA, HEART, METABOLISM, FIRE EXTINGUISHERS
Field(s)/Group(s):
Toxicology
Keyword(s):
*METHANE BROMOTRIFLUORO
Report Date:
1971 Dec 30