Hyperbaric Air and Corneal Vascularization

reportActive / Technical Report | Accession Number: AD0732398 | Open PDF

Abstract:

Hypoxia is one of the factors postulated as promoting vascularization of the cornea. However, previous experiments designed to increase tissue oxygen for short or intermittent periods have had no effect in retarding neovascularization. The present study utilized rabbit exposure to hyperbaric air for continuous periods of up to two weeks to increase tissue oxygen, and demonstrated no effect on the neovascularization caused by sodium hydroxide burns of the cornea. This confirms previous experimental results and tends to rule out inadequate time periods or intermittency of exposure as factors in previous negative results.

Author(s):
Kaiser, Robert J. ; Klopp, Donald W.
Author Organization(s):
NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
Descriptive Note:
Final rept.
Supplementary Note:
DOI: 10.21236/AD0732398
Pagination:
0014

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
NSMRL-668
Project Number(s):
MR011.01
Monitor Series:
NAVMED
 Subject Terms
Joint Capability Areas:
JCA_1.2.7_Experimentation
Communities of Interest:
Biomedical
Descriptor(s):
*BLOOD VESSELS, *HYPERBARIC CONDITIONS, *HYPOXIA, BURNS(INJURIES), CORNEA, EXPERIMENTAL DATA, OPHTHALMOLOGY, OXYGEN, PRESSURE, RABBITS, SCIENTIFIC RESEARCH
Field(s)/Group(s):
Medicine and Medical Research, Stress Physiology
Keyword(s):
*HYPERBARIC ATMOSPHERES
Report Date:
1971 Jun 24