Effects of Inhalation of Freon 113 on Laboratory Animals,

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Abstract:

Four monkeys, 8 dogs, 40 mice and 50 rats were exposed continuously to 2000 ppm Freon 113 in a Thomas Dome for 14 days. This exposure produced no mortalities nor adverse symptomatology. There were no significant alterations in hematological values, clinical chemistries, electroencephalographic findings, body weights, or organ to body weight ratios. The effect of 2 Freon 113 on nicotinic transmission through the stellate ganglion of the spinal dog was also evaluated. This exposure induced a reduction in nicotinic transmission comparable to 2 halothane. The effects of this compound on muscarinic ganglionic transmission were not evaluated. Author

Author(s):
Carter, Vernon L. ; Chikos, Paul M. ; Macewen, James D. ; Back, Kenneth C.
Author Organization(s):
AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO
Supplementary Note:
Presented at Annual Conference on Environmental Toxicology (1st) Fairborn, Ohio, 9-11 Sep 70, sponsored by SysteMed Corp., Dayton, Ohio.
Pagination:
0018

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AMRL-TR-70-102-Paper-20
Project Number(s):
AF-6302
 Subject Terms
Joint Capability Areas:
JCA_6.1_Information Transport; JCA_6_Net Centric
Communities of Interest:
No COI(s) Identified
Descriptor(s):
DOSAGE, EXPOSURE(GENERAL), PHARMACOLOGY, GANGLIA, RESPIRATION, PATHOLOGY, PHYSIOLOGY, ANESTHETICS, BLOOD CHEMISTRY, PSYCHOPHYSIOLOGY, DOGS, MICE, RATS, BIOASSAY
Field(s)/Group(s):
Toxicology, Pharmacology
Report Date:
1970 Dec 01