Classification of Immunoglobulins Against Rabies Virus in Human Sera.

The specific immunoglobulin response to an antigenic stimulus has been shown to be dependent upon the chemical composition of the antigen, its physical state, and the route and timing of administration. In the present study, a particulate protein antigen, inactivated rabies virus, was administered therapeutically to a group of human patients on multiple occasions. The result was the formation of the specific serum neutralizing antibody of at least two molecular classes IgM and IgG. In this instance, IgM class of SN antibody was demonstrated to constitute a significant proportion of the total SN titer for at least 41 days after the initiation of therapy, making up more than 34 of the total SN titer for the first two weeks of this period.