THE ROLE OF GAMMA-AMINOBUTYRIC ACID IN THE INHIBITORY MECHANISM OF MAMMALIAN CENTRAL NERVOUS SYSTEM.

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Abstract:

Since nerve cells of large sizes were isolated from various nuclei of cat brain stem for each isolated nerve cell, its gamma aminobutyric acid GABA content was measured and the GABA concentration calculated. In two cats, cerebellar vermis was removed, and 9 and 40 days after the operation, large cells were dissected out from Deiters nucleus. GABA concentrations in the isolated nerve cells of the operated cats were Deiters cells, dorsal part, 1.7 plus or minus 0.6 mM Deiters cells, ventral part, 2.7 plus or minus 0.4 mM. Purkinje neurones of cerebellar vermis send their axons to the dorsal part of Deiters nucleus. The present results suggest that GABA exists in a high concentration in Purkinje axon terminals attached to the nerve cell bodies of dorsal part of Deiters nucleus. Author

Author(s):
Otsuka, Masanori
Author Organization(s):
TOKYO MEDICAL AND DENTAL UNIV (JAPAN) DEPT OF PHARMACOLOGY
Descriptive Note:
Rept. no. 3 (Final) May 69-May 70,
Pagination:
0012

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
ARDG(FE)-337-3
Contract/Grant Number(s):
DA-CRD-AFE-S92-544-67-G66
Task Number(s):
977701
Project Number(s):
AF-9777
Monitor Series:
337-3
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*AMINO ACIDS, *CENTRAL NERVOUS SYSTEM, NERVE CELLS, PHYSIOLOGY, CATS, NERVE IMPULSES, JAPAN
Field(s)/Group(s):
Anatomy and Physiology
Keyword(s):
*BUTYRIC ACID AMINO
Report Date:
1970 May 01