POTENTIAL ANTI-MALARIALS BASED ON QUINOLINE-7-CARBOXYLIC ACID.

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Abstract:

Several routes to unsubstituted 7-aminoalcohol-quinolines were investigated, none have yielded any of the required compound. A scheme of synthesis for 2,7-disubstituted quinolines was investigated. Antimalarial activity has been associated with one of these compounds, 2-phenyl-7-carboxyquinoline and the synthesis of a series of such compounds, with varients in the 2-position, was undertaken. Alternative routes for the conversion of 2-aryl-7-methyl or 7-carboxyquinoline into 2-aryl-7-aminoalcohol quinoline derivatives are outlined. Author

Author(s):
Bridgwater, Roden J.
Author Organization(s):
MAYBRIDGE CHEMICAL CO LTD TINTAGEL (ENGLAND)
Descriptive Note:
Final technical rept. 1 Jan-31 Dec 68,
Pagination:
0033

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DAJA37-68-C-0436
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*ANTIMALARIALS, *QUINOLINES, AMINES, SYNTHESIS(CHEMISTRY), CARBOXYLIC ACIDS, UNITED KINGDOM
Field(s)/Group(s):
Pharmacology, Organic Chemistry
Report Date:
1969 Jul 15