INSULIN-INHIBITORY FACTOR IN HUMAN BLOOD: ROLE IN THE CHARCOAL RADIOIMMUNOASSAY.

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Abstract:

The insulin-inhibitory factor in human blood was studied. The results of a recovery study with a single-antibody assay the charcoal radioimmunoassay were compared to those with a two-antibody assay to determine whether inhibition occurred between insulin and the first antibody or between the first and the second antibody. The single-antibody assay did not show an insulin-inhibitory factor, but the two-antibody radioimmunoassay did show an inhibitor. The inhibitor must therefore act between the anti-human gamma globulin antibody and the anti-insulin antibody to block the reaction. The exact nature of the inhibitor is as yet unknown. Author

Author(s):
Logsdon, Donald F., Jr. ; Green, James F.
Author Organization(s):
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
Descriptive Note:
Rept. for Jan-Jun 68,
Pagination:
0010

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
SAM-TR-135
Task Number(s):
775502
Project Number(s):
AF-7755
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
RADIOBIOLOGY, MEDICINE, BLOOD, ANTIGENS, ANTIBODIES, HUMANS, CHARCOAL, LABELED SUBSTANCES
Field(s)/Group(s):
Medicine and Medical Research, Radiobiology
Keyword(s):
BIOASSAY, RADIOIMMUNITY
Report Date:
1968 Dec 01