HOG CHOLERA VIRUS ATTENUATION IN TISSUE CULTURE,

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Abstract:

Hog cholera virus has been successfully attenuated in tissue culture. After adaptation of the crude virus to cultures of hog embryo kidney cells, it was passaged 30-40 times. Virulence was retained, while the virus became cytopathogenic and only slightly viable. During stabilization by means of 7-fold passaging of cultured virus to a baby pig, the virus established its potential viability. The stabilized virus was repeatedly passaged 5 times in hog embryo kidney cell culture. After secondary stabilization of cultured virus was achieved by means of a single passage through a baby pig, blood from this pig was used as a source of virus for adaptation to transplanted cells. Injection of this virus immunized baby hogs against subsequent infection by crude virus. Author

Author(s):
Airapetyan, V. G. ; Khachatryan, A. B. ; Pogosyan, A. A.
Author Organization(s):
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER WASHINGTON D C
Supplementary Note:
Trans. of Veterinariya (USSR) v44 n12 p27-29 1967.
Annotation:
Hog cholera virus attenuation in tissue culture--Translation.
Pagination:
0009

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
FSTC-HT-23-1050-68
Project Number(s):
FSTC-0903002, FSTC-92236282301
 Subject Terms
Joint Capability Areas:
JCA_3.2_Engagement; JCA_3_Force Application; JCA_3.2.2_Non-Kinetic Means; JCA_6.4_Information Assurance; JCA_6_Net Centric; JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_8_Building Partnerships
Communities of Interest:
No COI(s) Identified
Descriptor(s):
(*CHOLERA, VIRUSES), SWINE, ATTENUATION, TISSUE CULTURE, IMMUNITY, TISSUE CULTURE CELLS, EMBRYOS, IMMUNITY, STABILIZATION, VACCINES, USSR
Field(s)/Group(s):
Animal Husbandry and Veterinary Medicine, Microbiology
Keyword(s):
TRANSLATIONS
Report Date:
1969 Mar 10