IMMUNIZATION EFFICIENCY IN VARIOUS MODES OF ADMINISTRATION OF THE LIVE BRUCELLOSIS VACCINE

Intracutaneous immunization of guinea pigs with small doses 100,000 microbial cells of live brucellosis vaccine from the Br. abortus No. 19 strain caused a more expressed immunization process than the subcutaneous immunization with the same doses, which was confirmed by the accumulation of specific antibodies and the allergic reorganization of the animal organism. The injection of a minimum immunizing dose under the skin did not stimulate the allergization of the guinea pigs. This was probably connected with the insufficient involvement of the skin covering in the immunization process. The effectiveness of the intracutaneous vaccination of animals with live brucellosis vaccine depended not only on the dose and site of administration of the antigen, but also on the number of points of application of the antigen administration of the minimum immunizing dose 100,000 of brucellae in 2 and 4 points caused a more active immunization process than the administration of the same dose of vaccine in 1 point.