ANTHRAX TOXIN: PRIMARY SITE OF ACTION

reportActive / Technical Report | Accession Number: AD0671380 | Open PDF

Abstract:

Administration of anthrax toxin via the cerebrospinal fluid demonstrates positively that the toxin alters the bodys physiology, primarily via the central nervous system, and kills by terminal anoxia mediated by the central nervous system. The use of a positive-pressure respirator and isoproterenol prevented death in animals that had received lethal doses of toxin. This demonstration of therapy for a lethal bacterial toxin opens new avenues of investigation.

Author(s):
Remmele, Norman S. ; Klein, Frederick ; Vick, James A. ; Walker, Jerry S. ; Mahlandt, Bill G. ; Lincoln, Ralph E.
Author Organization(s):
FORT DETRICK FREDERICK MD
Supplementary Note:
Availability: Published in Jnl. of Infectious Diseases, v118 p104-13 Feb 1968.
Annotation:
Reprint: Anthrax toxin: Primary site of action.
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release, Document Partially Illegible
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited. Document Partially Illegible.

RECORD

Collection: TR
Identifying Numbers
Monitor Series:
ABL/MD
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*TOXINS AND ANTITOXINS, *BACILLUS ANTHRACIS, TOXICITY, DOSAGE, CHEMOTHERAPY, ANOXIA, CEREBROSPINAL FLUID, SYMPATHOMIMETIC AGENTS, RESPIRATORS, INJECTIONS(MEDICINE), INFECTIOUS DISEASES, CENTRAL NERVOUS SYSTEM
Field(s)/Group(s):
Medicine and Medical Research, Toxicology
Keyword(s):
ISOPROTERENOL
Report Date:
1968 Feb 01