STUDIES IN SEPTIC AND IRREVERSIBLE SHOCK.
Abstract:
During this period research activities were concentrated on the following subjects 1 Studies on the incidence and cyclic variations of antibiotic resistance of Staphylococcus aureus recovered from surgical infections, including the newly discovered UC-18 and UC-13 strains. 2 Study of 539 cases of septicemia showing a 12-fold increase in gram-negative sepsis during the past 11 years and a high relationship of shock with mortality in sepsis. 3 Animal experimentation to measure the various physiological, chemical and pathological effects of purified bacterial toxins on the circulatory system and blood with emphasis on the function of the heart, pressure relationships in the cardiac chambers, peripheral vascular resistance, and function of the kidneys and liver. 4 Further studies on in vivo production of toxins by Staphylococcus aureus. 5 Clinical and laboratory studies of circulatory failure and shock-like conditions developed in clinical patients with a variety of surgical infections. 6 Preliminary observations of coagulation disorders and hemorrhage occurring in patients with sepsis and shock. Author