THE SIGNIFICANCE OF TYPE E BOTULINUM TOXIN ACTIVATION IN THE LABORATORY DIAGNOSIS OF BOTULISM

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Abstract:

Conclusions On artificial nutrient media, Cl. botulinum produces a toxin and a nontoxic prototoxin. The latter may be transformed into a toxin due to the action of various enzymes pancreatin, proteinase of Cl. sporogenes. when botulinum prototoxin type E reaches the digestive tract its activation by enzymes takes place. As a result of this the toxic effect on the organism is strengthened. During the investigation of various materials food products, discharges from a patient, section material, original seedings for the presence of botulinum toxins, it is necessary to subject the nontoxic filtrates to activation by pancreatin, and after this set up biological tests and the neutralization reaction with antibotulinum serum type E.

Author(s):
Bulatova, T. I.
Author Organization(s):
ARMY BIOLOGICAL LABS FREDERICK MD
Supplementary Note:
Trans. of Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii, (USSR), v42, n8, p97-101, 1965. Included in TT-64-51183.
Annotation:
THE SIGNIFICANCE OF TYPE E BOTULINUM TOXIN ACTIVATION IN THE LABORATORY DIAGNOSIS OF BOTULISM -- Translation.
Pagination:
0010

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
TRANS-1406
Monitor Series:
ABL/MD
 Subject Terms
Joint Capability Areas:
JCA_8.1.1_Inform Domestic and Foreign Audiences; JCA_8.1_Communicate; JCA_8_Building Partnerships
Communities of Interest:
Biomedical
Descriptor(s):
*CLOSTRIDIUM BOTULINUM, USSR, TOXICITY, ENZYMES, CULTURE MEDIA, DIAGNOSIS(MEDICINE), TRANSLATIONS, TOXINS AND ANTITOXINS
Field(s)/Group(s):
Microbiology
Keyword(s):
FOREIGN REPORTS
Report Date:
1963 Jan 14