RESEARCH ON THERAPY OF PULMONARY EDEMA ASSOCIATED WITH OXIDIZERS

reportActive / Technical Report | Accession Number: AD0628593 | Open PDF

Abstract:

An evaluation was made of candidate therapeutic agents for the treatment of acute pulmonary edema resulting from nitrogen dioxide exposure. Treatments consisting of hyperbaric air and oxygen tracheal toilet ethyl, isopropyl, and octyl alcohol vapors hydralazine bethanechol physostigmine and isoproterenol aerosols produced no change in the mortality, survival time, or lungbody weight ratios of rats suffering from N02-induced acute pulmonary edema. Rutin in large doses caused a decrease in mortality and an increase in survival time of exposed rats. Intravenous infusion of isoproterenol caused a decrease in mortality in rabbits exposed to N02. The effectiveness of hyperbaric oxygen, hydrocortisone, rutin and bethanechol against moderate exposure to N02 was determined by solvent uptake measurements with rats. Oxygen administered 4 hours after exposure increased solvent uptake. There were no significant effects due to the other compounds.

Author(s):
Hine, Charles H. ; Cavalli, Richard D. ; Wright, Robert R.
Author Organization(s):
HINE LABS INC SAN FRANCISCO CA
Descriptive Note:
Final rept. 15 May 1964-30 Jun 1965
Supplementary Note:
DOI: 10.21236/AD0628593
Pagination:
0050

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release
Distribution Statement:
Approved For Public Release; Distribution Is Unlimited.

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AMRL-TR-65-178
Contract/Grant Number(s):
AF 33(615)-1781
Task Number(s):
630202
Project Number(s):
AF-6302
Monitor Series:
TR-65-178, AMRL
 Subject Terms
Joint Capability Areas:
JCA_1.4_Force Support; JCA_1.4.1_Force Health Protection; JCA_7.2.1_Mitigate Lethal Effects; JCA_7.2_Mitigate; JCA_7_Protection; JCA_1.2.7_Experimentation; JCA_8.2.4_Leverage Capacities and Capabilities of Security Establishments; JCA_8.2_Shape; JCA_8_Building Partnerships; JCA_1.4.2_Health Service Delivery; JCA_5_Command and Control; JCA_1_Force Support; JCA_4.5.4_Requirements Definition; JCA_4.5_Operational Contract Support; JCA_6.4.1_Secure Information Exchange; JCA_1.2.5_Lessons Learned; JCA_1.3_Human Capital Management; JCA_3.2_Engagement; JCA_3_Force Application; JCA_6.4_Information Assurance; JCA_6_Net Centric
Communities of Interest:
Biomedical
Descriptor(s):
*LUNG, *OXIDIZERS, *EDEMA, TOXICITY, NITROGEN COMPOUNDS, DIOXIDES, CHEMOTHERAPEUTIC AGENTS, THERAPY, OXYGEN
Field(s)/Group(s):
Pharmacology
Report Date:
1965 Nov 01