EVIDENCE FOR A ROLE OF DOPAMINE IN EXTRAPYRAMIDAL FUNCTIONS,

reportActive / Technical Report | Accession Number: AD0617981 | Need Help?

Abstract:

Dopamine 3-hydroxytyramine is the immediate precursor in the biosynthesis of noradrenaline. In brain it probably also serves as a neurotransmitter, particularly in the extrapyramidal system. About 80 of the brain dopamine occur in the neostriatum. The intraneuronal localization of dopamine was demonstrated by means of histochemical techniques. Reserpine causes dopamine to disappear from the brain and produces a parkinsonian syndrome. The central actions of reserpine can be partially counteracted by increasing the concentration of dopamine in brain through administration of the precursor L-3,4-dihydrophenylalanineL-DOPA. In brains of parkinson patients the concentration of dopamine has been found markedly lowered the parkinson syndrome is favourably influenced by increasing the dopamine concentration through L-DOPA administration. Author

Author(s):
Carlsson, A.
Author Organization(s):
GOTEBORG UNIV (SWEDEN)
Supplementary Note:
Pub. in Acta Neurovegetativa v26 n4 p484-93 1964 (Copies available only to DDC users).
Annotation:
Reprint: Evidence for a role of dopamine in extrapyramidal functions.
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
AFOSR-65-0943
Contract/Grant Number(s):
AF EOAR61 44
Task Number(s):
977701
Project Number(s):
9777
Monitor Series:
65-0943
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*NERVOUS SYSTEM DISEASES, AMINES, BRAIN, AMINES, NOREPINEPHRINE, BIOSYNTHESIS, HISTOCHEMISTRY, RESERPINE, PHENYLALANINE, PARALYSIS, SWEDEN
Keyword(s):
AMINOETHYL PYROCATECHOLS, HISTOCHEMISTRY, PARKINSONISM
Report Date:
1964 Jan 01